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KMID : 0870520180220020059
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Journal of Korean Academy of Addiction Psychiatry
2018 Volume.22 No. 2 p.59 ~ p.63
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Craving : Biological Understanding and Therapeutic Approach
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Han Chang-Woo
Choi Young-Sook
Kim Young-Ho
Lee Koun-Seok
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Abstract
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Objectives: Craving is defined as the desire for using the substance. It plays an important role in the recurrence of substance-related disorder. The purpose of this review was to summarize the pathophysiology, pharmacological and psychological treatment of craving.
Methods: We searched and reviewed articles of craving for substance.
Results: The neurotransmitters involved in craving are dopamine and serotonin. Dopamine acts on the enhancement of action, while serotonin acts by inhibiting the release of γ-Aminobutyric acid. Both acamprosate and naltrexone could be used for craving treatment. And cognitive behavioral therapeutic methods are also being applied to treatment.
Conclusions: The systematic management of craving aimed at preventing the recurrence of substance-related disorders could be resulted in improved compliance and reducing patient recurrence and treatment costs.
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KEYWORD
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Craving, Addiction, Alcohol, Substance-related disorders, Pathophysiology
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